Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins

نویسندگان

چکیده

Potential effects of tea and its constituents on SARS-CoV-2 infection were assessed in vitro. Infectivity was decreased to 1/100 undetectable levels after a treatment with black tea, green roasted or oolong for 1 min. An addition (−) epigallocatechin gallate (EGCG) significantly inactivated SARS-CoV-2, while the same concentration theasinensin A (TSA) galloylated theaflavins including theaflavin 3,3′-di-O-gallate (TFDG) had more remarkable anti-viral activities. EGCG, TSA, TFDG at mM, 40 µM, 60 respectively, which are comparable concentrations these compounds beverages, reduced infectivity virus, viral RNA replication cells, secondary virus production from cells. inhibited interaction between recombinant ACE2 RBD S protein. These results suggest potential usefulness prevention person-to-person transmission novel coronavirus.

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ژورنال

عنوان ژورنال: Molecules

سال: 2021

ISSN: ['1420-3049']

DOI: https://doi.org/10.3390/molecules26123572